Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

Therapeutic proteins together with antibodies and Fc-fusion proteins bear numerous chemical modifications throughout cell tradition, purification, storage and in human circulation. They’re additionally uncovered to harsh situations throughout stress research, together with elevated temperature, extremes of pH, pressured oxidation, physiological pH, UV mild to evaluate the potential degradation pathways and suitability of strategies for detecting them. A few of these modifications are positioned on residues in binding areas, resulting in lack of binding and efficiency and categorised as vital high quality attributes.

At present, criticality of modifications is assessed by a laborious means of amassing antibody fractions from the mushy chromatography strategies ion change and hydrophobic interplay chromatography and characterizing the fractions one-by-one for efficiency and chemical modifications. Right here, we describe a technique for large-scale, parallel identification of all vital chemical modifications in a single experiment.

In step one, the antibody is harassed by one or a number of stress strategies. It’s then blended with goal protein and separated by size-exclusion chromatography (SEC) on sure antibody-target complicated and unbound antibody. Peptide mapping of fractions and statistical evaluation are carried out to establish modifications on amino acid residues that have an effect on binding.

To establish the modifications resulting in slight decreases in binding, aggressive SEC of antibody and antigen mixtures was developed and described in a companion research by Shi et al, the place goal protein is supplied at decrease stage, beneath the stoichiometry. The newly described methodology was efficiently correlated to crystallography for assessing criticality of chemical modifications and paratope mapping. It’s extra delicate to low-level modifications, higher streamlined and platform prepared.

Identification of vital chemical modifications by dimension exclusion chromatography of harassed antibody-target complexes with aggressive binding

Chemical modifications (attributes) within the binding areas of harassed therapeutic proteins might have an effect on binding to focus on and efficacy of therapeutic proteins. The tactic introduced right here describes the criticality evaluation of therapeutic antibody modifications by size-exclusion chromatography (SEC) of aggressive binding between a harassed antibody and its goal, human epidermal progress issue receptor-2 (HER2), adopted by SEC fractionation and peptide mapping characterization of sure and unbound antibodies.

When harassed antibody and its goal had been blended at a stoichiometric molar ratio of 1:2, solely antibody-receptor complicated eluted from SEC, indicating that binding was not decreased to interrupt the complicated. When a smaller quantity of the receptor was supplied (1:1), the antibody species with modifications decreasing binding eluted as unbound from SEC, whereas the antibody-receptor complicated eluted because the sure fraction. Peptide mapping revealed ratios of modifications between unbound and sure fractions.

Statistical evaluation after triplicate measurements (n = 3) indicated that heavy chain (HC) D102 isomerization and light-weight chain (LC) N30 deamidation had been four-fold greater in unbound fraction with excessive statistical significance. Though HC N55 deamidation and M107 oxidation had been additionally ample, they weren’t statistically completely different between unbound and sure.

Our findings agree with beforehand printed efficiency measurements of collected CEX fractions and the crystal construction of antibody and HER2. General, aggressive SEC of harassed antibody-receptor combination adopted by peptide mapping is a great tool in revealing vital residues and modifications concerned within the antibody-target binding, even when they elute as a posh from SEC when blended at 1:2 stoichiometric ratio.

Fast Dedication of Antibody-Antigen Affinity by Mass Photometry

Measurements of the specificity and affinity of antigen-antibody interactions are critically necessary for medical and analysis purposes. On this protocol, we describe the implementation of a brand new single-molecule method, mass photometry (MP), for this goal. MP is a label- and immobilization-free method that detects and quantifies molecular lots and populations of antibodies and antigen-antibody complexes on a single-molecule stage. MP analyzes the antigen-antibody pattern inside minutes, permitting for the exact dedication of the binding affinity and concurrently offering data on the stoichiometry and the oligomeric state of the proteins.

Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

It is a easy and simple method that requires solely picomole portions of protein and no costly consumables. The identical process can be utilized to review protein-protein binding for proteins with a molecular mass bigger than 50 kDa. For multivalent protein interactions, the affinities of a number of binding websites might be obtained in a single measurement.

Nevertheless, the single-molecule mode of measurement and the shortage of labeling imposes some experimental limitations. This methodology offers the most effective outcomes when utilized to measurements of sub-micromolar interplay affinities, antigens with a molecular mass of 20 kDa or bigger, and comparatively pure protein samples. We additionally describe the process for performing the required becoming and calculation steps utilizing primary information evaluation software program.

Detection and distribution of anti-leptospiral antibody amongst canine and their handlers

The incidence of leptospirosis appears to be on the rise and could possibly be an alarming oblique indication of a world re-emergence. It’s a potential public well being menace when canine are alleged to be concerned within the transmission of leptospirosis by means of potential subclinical harbouring of Leptospira spp. and subsequent shedding into the atmosphere. This research aimed to detect anti-leptospiral antibodies amongst canine and their handlers utilizing the microscopic agglutination take a look at (MAT).

Blood samples from 266 apparently wholesome canine and 194 canine handlers had been collected at 4 working canine organisations and 4 canine shelters. Serum samples had been examined utilizing MAT in opposition to 20 leptospiral serovars with a cut-off titre >=1:100 (canine) and >=1:50 (canine handlers). Seventy canine (70/266; 26.3%) had been seropositive primarily in opposition to serovars Icterohaemorrhagiae, Ballum, Bataviae and Javanica (titres ranged: 1:100-1:800).

Sixty-seven canine handlers (67/194; 34.5%) had been seropositive primarily in opposition to serovars Grippotyphosa, Icterohaemorrhagiae and Malaysia (titres ranged: 1:50-1:200). Canines had been seropositive as a result of publicity, vaccination or lively an infection. Seropositive canine handlers may point out publicity or lively an infection.

D- dimer Assay Kit
BC079-R130ml1R210ml1 R1:30ml×1R2:10ml×1
EUR 500

D- dimer Assay Kit
SH0029 R1：30ml×1R2：10ml×1
EUR 1280

D-Biotin Dimer Acid
B390650 10mg
EUR 11274
Description: 1163708-46-0

Rat D Dimer ELISA kit
E02D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat D Dimer ELISA kit
E02D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat D Dimer ELISA kit
E02D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig D Dimer ELISA kit
E07D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig D Dimer ELISA kit
E07D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig D Dimer ELISA kit
E07D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog D Dimer ELISA kit
E08D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog D Dimer ELISA kit
E08D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog D Dimer ELISA kit
E08D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat D Dimer ELISA kit
E01A12866 96T
EUR 700
Description: ELISA

Goat D Dimer ELISA kit
E01A47775 96T
EUR 700
Description: ELISA

Goat D Dimer ELISA kit
E06D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat D Dimer ELISA kit
E06D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat D Dimer ELISA kit
E06D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse D Dimer ELISA kit
E01A21606 96T
EUR 700
Description: ELISA

Human D Dimer ELISA kit
E01A4102 96T
EUR 700
Description: ELISA

Mouse D Dimer ELISA kit
E03D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse D Dimer ELISA kit
E03D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse D Dimer ELISA kit
E03D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human D Dimer ELISA kit
E01D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human D Dimer ELISA kit
E01D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human D Dimer ELISA kit
E01D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep D Dimer ELISA kit
E01A100068 96T
EUR 700
Description: ELISA

Human D Dimer ELISA Kit
MBS723523-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human D Dimer ELISA Kit
MBS723523-48StripWells 48-Strip-Wells
EUR 485

Human D Dimer ELISA Kit
MBS723523-5x96StripWells 5x96-Strip-Wells
EUR 3020

Human D Dimer ELISA Kit
MBS723523-96StripWells 96-Strip-Wells
EUR 690

Positive Control for Anti-Rat MEH Antibody
MEHCON 100 uL
EUR 98

Canine D Dimer ELISA kit
E01A65207 96T
EUR 700
Description: ELISA

Monkey D Dimer ELISA kit
E01A73921 96T
EUR 700
Description: ELISA

Rabbit D Dimer ELISA kit
E01A30343 96T
EUR 700
Description: ELISA

Bovine D Dimer ELISA kit
E01A82640 96T
EUR 700
Description: ELISA

Rabbit D Dimer ELISA kit
E04D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit D Dimer ELISA kit
E04D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit D Dimer ELISA kit
E04D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey D Dimer ELISA kit
E09D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey D Dimer ELISA kit
E09D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey D Dimer ELISA kit
E09D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Positive Control for Anti-Rat CYP2C Antibody
P2CCON 100 uL
EUR 98

Positive Control for Anti-Rat CYP2D Antibody
P2DCON 100 uL
EUR 98

Positive Control for Anti-Rat CYP2B1 Antibody
P2B1PTCON 100 uL
EUR 98

Positive Control for Anti-Rat CYP3A2 Antibody
P3A2PTCON 100 uL
EUR 98

Positive Control for Anti-Human CYP3A Antibody
P3ACON 100 uL
EUR 98

Positive Control for Anti-Human CYP1B1 Antibody
PH1B1CON 100 uL
EUR 98

Positive Control for Anti-Human CYP2E1 Antibody
P2E1PTCON 100 uL
EUR 98

Positive Control for Anti-Human CYP1A2 Antibody
P1A2CON 100 uL
EUR 98

Porcine D Dimer ELISA kit
E01A56492 96T
EUR 700
Description: ELISA

Chicken D Dimer ELISA kit
E01A91362 96T
EUR 700
Description: ELISA

Hamster D Dimer ELISA kit
E01A104918 96T
EUR 700
Description: ELISA

Hamster D Dimer ELISA Kit
MBS7275543-10x96StripWells 10x96-Strip-Wells
EUR 5685

Hamster D Dimer ELISA Kit
MBS7275543-48StripWells 48-Strip-Wells
EUR 485

Hamster D Dimer ELISA Kit
MBS7275543-5x96StripWells 5x96-Strip-Wells
EUR 3020

Hamster D Dimer ELISA Kit
MBS7275543-96StripWells 96-Strip-Wells
EUR 690

Positive Control for Anti-Rat CHP2B1/2 Antibody
P2B12PTCON 100 uL
EUR 98

Positive Control for Anti-Rat CYP1A1/1A2 Antibody
P1ACON 100 uL
EUR 98

Positive Control for Anti-Human Cytochrome b5 Antibody
Cb5CON 100 uL
EUR 98

Ertapenem Dimer Form D Impurity
E635025 0.5mg
EUR 800
Description: 1199797-41-5

Guinea Pig D Dimer ELISA kit
E01A39057 96T
EUR 700
Description: ELISA

Guinea pig D Dimer ELISA kit
E05D0224-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig D Dimer ELISA kit
E05D0224-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig D Dimer ELISA kit
E05D0224-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

De-alpha-D-glucopyranoside Canagliflozin Dimer
D230240 25mg
EUR 1200

Anthralin dimer
A420020 100mg
EUR 800
Description: 31991-54-5

Efficiency Box--HRP conjugated secondary antibodies
EB-1 81 vials
EUR 193.2

BG dimer
T40322-10mg 10mg Ask for price
Description: BG dimer

BG dimer
T40322-1g 1g Ask for price
Description: BG dimer

BG dimer
T40322-1mg 1mg Ask for price
Description: BG dimer

BG dimer
T40322-50mg 50mg Ask for price
Description: BG dimer

BG dimer
T40322-5mg 5mg Ask for price
Description: BG dimer

BG dimer
MBS5800586-5mg 5(mg
EUR 915

BG dimer
MBS5800586-5x5mg 5x5(mg
EUR 3970

BG dimer
HY-139673 Get quote Ask for price
Description: BG dimer is a molecular dimer organic luminogen with aggregation-induced emission.

PGE1 Dimer
P380080 10mg
EUR 5000

SLURP1 Dimer
pro-2295 2µg
EUR 60
Description: Recombinant Human Secreted LY6PLAUR Domain Containing 1 Dimer

PBD dimer-2
HY-148424 10 mg
EUR 3787.94
Description: PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer[1][2].

Esmolol Dimer
E668030 100mg
EUR 1652
Description: 98903-89-0

Apixaban Dimer
A726725 10mg
EUR 775

Capzimin dimer
112215 10.0mg
EUR 360

Cefaclor Dimer
C302620 250mg
EUR 3000
Description: 142975-51-7

Afatinib Dimer
A355310 25mg
EUR 12800

Cefoxitin Dimer
C243220 100mg
EUR 9200

Closantel Dimer
C587385 25mg
EUR 3000
Description: 2731038-10-9

Gestodene Dimer
G368275 50mg
EUR 7600

Ibuprofen Dimer
I140040 10mg
EUR 788
Description: 2575516-43-5

Linezolid Dimer
L466520 2.5mg
EUR 1646
Description: 908143-04-4

Linezolid Dimer
L466850 100mg
EUR 3000

Ibrutinib dimer
T11602-10mg 10mg Ask for price
Description: Ibrutinib dimer

Ibrutinib dimer
T11602-1g 1g Ask for price
Description: Ibrutinib dimer

Ibrutinib dimer
T11602-1mg 1mg Ask for price
Description: Ibrutinib dimer

Ibrutinib dimer
T11602-50mg 50mg Ask for price
Description: Ibrutinib dimer

Ibrutinib dimer
T11602-5mg 5mg Ask for price
Description: Ibrutinib dimer

Tamoxifen Dimer
T006100 50mg
EUR 228
Description: 1346606-51-6

Quercetin dimer
TN5488-10mg 10mg Ask for price
Description: Quercetin dimer

Quercetin dimer
TN5488-1g 1g Ask for price
Description: Quercetin dimer

Quercetin dimer
TN5488-1mg 1mg Ask for price
Description: Quercetin dimer

Quercetin dimer
TN5488-50mg 50mg Ask for price
Description: Quercetin dimer

Quercetin dimer
TN5488-5mg 5mg Ask for price
Description: Quercetin dimer

Quercetin dimer
MBS5787601-5mg 5(mg
EUR 570

Quercetin dimer
MBS5787601-5x5mg 5x5(mg
EUR 2410

Ibrutinib dimer
HY-136113 Get quote Ask for price
Description: Ibrutinib dimer is a Dimer of Ibrutinib. Ibrutinib dimer is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

Oxytocin antiparallel dimer
T39420-10mg 10mg Ask for price
Description: Oxytocin antiparallel dimer

Oxytocin antiparallel dimer
T39420-1g 1g Ask for price
Description: Oxytocin antiparallel dimer

Oxytocin antiparallel dimer
T39420-1mg 1mg Ask for price
Description: Oxytocin antiparallel dimer

Oxytocin antiparallel dimer
T39420-50mg 50mg Ask for price
Description: Oxytocin antiparallel dimer

Oxytocin antiparallel dimer
T39420-5mg 5mg Ask for price
Description: Oxytocin antiparallel dimer

Oxytocin antiparallel dimer
MBS5799907-5mg 5(mg
EUR 915

Oxytocin antiparallel dimer
MBS5799907-5x5mg 5x5(mg
EUR 3970

Azilsartan Dimer
A926755 100mg
EUR 11200

Azilsartan Dimer
A926920 100mg
EUR 995
Description: 1604812-35-2

Ethoxyquin Dimer
462121 1.0mg
EUR 289

Ethoxyquin Dimer
E892810 10mg
EUR 249
Description: 74681-77-9

Vilanterol Dimer
D432360 100mg
EUR 23000

Eletriptan Dimer
E526000 25mg
EUR 1800

Boceprevir Dimer
B674530 50mg
EUR 12900

Cefadroxil Dimer
C235775 100mg
EUR 3000
Description: 2378158-45-1

Clomiphene Dimer
C587010 50mg
EUR 9200

Ethoxyquin Dimer
T35620-10mg 10mg Ask for price
Description: Ethoxyquin Dimer

Ethoxyquin Dimer
T35620-1g 1g Ask for price
Description: Ethoxyquin Dimer

Ethoxyquin Dimer
T35620-1mg 1mg Ask for price
Description: Ethoxyquin Dimer

Ethoxyquin Dimer
T35620-50mg 50mg Ask for price
Description: Ethoxyquin Dimer

Ethoxyquin Dimer
T35620-5mg 5mg Ask for price
Description: Ethoxyquin Dimer

Formoterol Dimer
F693495 75mg
EUR 17000
Description: 1795129-59-7

Ivabradine Dimer
I477220 25mg
EUR 1750

Lovastatin Dimer
L472245 0.5mg
EUR 2302
Description: 149756-62-7

Lamivudine Dimer
L172480 100mg
EUR 1800

Nevirapine Dimer
N391290 10mg
EUR 8757
Description: 1391054-30-0

Mexiletine Dimer
M340805 100mg
EUR 1200
Description: 2059988-38-2

Pholcodine Dimer
P351525 100mg
EUR 1800

Primaquine Dimer
P733510 10mg
EUR 1200
Description: 148795-90-8

Psilocybin Dimer
P574830 75mg
EUR 4500

Raloxifene Dimer
R100040 50mg
EUR 3000
Description: 618902-12-8

Tizanidine Dimer
T102185 500mg
EUR 1200

Valdecoxib Dimer
V090020 100mg
EUR 181

Vardenafil Dimer
V098020 10mg
EUR 1454
Description: 1255919-03-9

Ethoxyquin Dimer
MBS5796941-1mg 1(mg
EUR 220

Ethoxyquin Dimer
MBS5796941-5mg 5(mg
EUR 705

Ethoxyquin Dimer
MBS5796941-5x5mg 5x5(mg
EUR 3025

Ethoxyquin Dimer
MBS6024191-1mg 1(mg
EUR 490

Ethoxyquin Dimer
MBS6024191-25mg 2.5mg
EUR 710

Ethoxyquin Dimer
MBS6024191-5x25mg 5x2.5mg
EUR 3040

Ethoxyquin dimer
HY-138291 1 mg
EUR 324.68
Description: Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10?mg/kg shows hepatotoxicity in mice[1].

Eltrombopag Dimer
E504000 50mg
EUR 9200

Ruxolitinib Dimer
R701855 100mg
EUR 7600

Roflumilast Dimer
R899390 250mg
EUR 1200
Description: 1352122-37-2

Simvastatin Dimer
S485010 10mg
EUR 283
Description: 476305-24-5

Terbutaline Dimer
T109780 100mg
EUR 7600

Tolterodine Dimer
T535810 250mg
EUR 4500
Description: 854306-72-2

Glycoaldehyde Dimer-13C4
G641152 10mg
EUR 1200

D-Dimer Antibody
20-abx100081
  • Ask for price
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

D-Dimer Antibody
abx020755-1mg 1 mg
EUR 844.8

D-Dimer Antibody
abx020756-1mg 1 mg
EUR 844.8

D-Dimer Antibody
abx020759-1mg 1 mg
EUR 861.6

D-Dimer Antibody
abx020761-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx020762-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx020763-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx020764-1mg 1 mg
EUR 861.6

D-Dimer Antibody
abx020765-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx020767-1mg 1 mg
EUR 1479.6

D-Dimer Antibody
abx020769-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx020770-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx020771-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx023583-1mg 1 mg
EUR 886.8

D-Dimer Antibody
abx023584-1mg 1 mg
EUR 886.8

This exhibits the potential of canine in sustaining and spreading the an infection in Malaysia. As a result of occupational threat on account of frequent contact with canine and publicity to contaminated environments, canine handlers needs to be made conscious of the presence of this zoonotic illness.

 

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