Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes
Therapeutic proteins together with antibodies and Fc-fusion proteins bear numerous chemical modifications throughout cell tradition, purification, storage and in human circulation. They’re additionally uncovered to harsh situations throughout stress research, together with elevated temperature, extremes of pH, pressured oxidation, physiological pH, UV mild to evaluate the potential degradation pathways and suitability of strategies for detecting them. A few of these modifications are positioned on residues in binding areas, resulting in lack of binding and efficiency and categorised as vital high quality attributes.
At present, criticality of modifications is assessed by a laborious means of amassing antibody fractions from the mushy chromatography strategies ion change and hydrophobic interplay chromatography and characterizing the fractions one-by-one for efficiency and chemical modifications. Right here, we describe a technique for large-scale, parallel identification of all vital chemical modifications in a single experiment.
In step one, the antibody is harassed by one or a number of stress strategies. It’s then blended with goal protein and separated by size-exclusion chromatography (SEC) on sure antibody-target complicated and unbound antibody. Peptide mapping of fractions and statistical evaluation are carried out to establish modifications on amino acid residues that have an effect on binding.
To establish the modifications resulting in slight decreases in binding, aggressive SEC of antibody and antigen mixtures was developed and described in a companion research by Shi et al, the place goal protein is supplied at decrease stage, beneath the stoichiometry. The newly described methodology was efficiently correlated to crystallography for assessing criticality of chemical modifications and paratope mapping. It’s extra delicate to low-level modifications, higher streamlined and platform prepared.
Identification of vital chemical modifications by dimension exclusion chromatography of harassed antibody-target complexes with aggressive binding
Chemical modifications (attributes) within the binding areas of harassed therapeutic proteins might have an effect on binding to focus on and efficacy of therapeutic proteins. The tactic introduced right here describes the criticality evaluation of therapeutic antibody modifications by size-exclusion chromatography (SEC) of aggressive binding between a harassed antibody and its goal, human epidermal progress issue receptor-2 (HER2), adopted by SEC fractionation and peptide mapping characterization of sure and unbound antibodies.
When harassed antibody and its goal had been blended at a stoichiometric molar ratio of 1:2, solely antibody-receptor complicated eluted from SEC, indicating that binding was not decreased to interrupt the complicated. When a smaller quantity of the receptor was supplied (1:1), the antibody species with modifications decreasing binding eluted as unbound from SEC, whereas the antibody-receptor complicated eluted because the sure fraction. Peptide mapping revealed ratios of modifications between unbound and sure fractions.
Statistical evaluation after triplicate measurements (n = 3) indicated that heavy chain (HC) D102 isomerization and light-weight chain (LC) N30 deamidation had been four-fold greater in unbound fraction with excessive statistical significance. Though HC N55 deamidation and M107 oxidation had been additionally ample, they weren’t statistically completely different between unbound and sure.
Our findings agree with beforehand printed efficiency measurements of collected CEX fractions and the crystal construction of antibody and HER2. General, aggressive SEC of harassed antibody-receptor combination adopted by peptide mapping is a great tool in revealing vital residues and modifications concerned within the antibody-target binding, even when they elute as a posh from SEC when blended at 1:2 stoichiometric ratio.
Fast Dedication of Antibody-Antigen Affinity by Mass Photometry
Measurements of the specificity and affinity of antigen-antibody interactions are critically necessary for medical and analysis purposes. On this protocol, we describe the implementation of a brand new single-molecule method, mass photometry (MP), for this goal. MP is a label- and immobilization-free method that detects and quantifies molecular lots and populations of antibodies and antigen-antibody complexes on a single-molecule stage. MP analyzes the antigen-antibody pattern inside minutes, permitting for the exact dedication of the binding affinity and concurrently offering data on the stoichiometry and the oligomeric state of the proteins.
It is a easy and simple method that requires solely picomole portions of protein and no costly consumables. The identical process can be utilized to review protein-protein binding for proteins with a molecular mass bigger than 50 kDa. For multivalent protein interactions, the affinities of a number of binding websites might be obtained in a single measurement.
Nevertheless, the single-molecule mode of measurement and the shortage of labeling imposes some experimental limitations. This methodology offers the most effective outcomes when utilized to measurements of sub-micromolar interplay affinities, antigens with a molecular mass of 20 kDa or bigger, and comparatively pure protein samples. We additionally describe the process for performing the required becoming and calculation steps utilizing primary information evaluation software program.
Detection and distribution of anti-leptospiral antibody amongst canine and their handlers
The incidence of leptospirosis appears to be on the rise and could possibly be an alarming oblique indication of a world re-emergence. It’s a potential public well being menace when canine are alleged to be concerned within the transmission of leptospirosis by means of potential subclinical harbouring of Leptospira spp. and subsequent shedding into the atmosphere. This research aimed to detect anti-leptospiral antibodies amongst canine and their handlers utilizing the microscopic agglutination take a look at (MAT).
Blood samples from 266 apparently wholesome canine and 194 canine handlers had been collected at 4 working canine organisations and 4 canine shelters. Serum samples had been examined utilizing MAT in opposition to 20 leptospiral serovars with a cut-off titre >=1:100 (canine) and >=1:50 (canine handlers). Seventy canine (70/266; 26.3%) had been seropositive primarily in opposition to serovars Icterohaemorrhagiae, Ballum, Bataviae and Javanica (titres ranged: 1:100-1:800).
Sixty-seven canine handlers (67/194; 34.5%) had been seropositive primarily in opposition to serovars Grippotyphosa, Icterohaemorrhagiae and Malaysia (titres ranged: 1:50-1:200). Canines had been seropositive as a result of publicity, vaccination or lively an infection. Seropositive canine handlers may point out publicity or lively an infection.
 D- dimer Assay Kit |
|
BC079-R130ml1R210ml1 |
ELK Biotech |
R1:30ml×1R2:10ml×1 |
EUR 500 |
 Rat D Dimer ELISA kit |
|
E01A12866 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Pig D Dimer ELISA kit |
|
E07D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Porcine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig D Dimer ELISA kit |
|
E07D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Porcine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig D Dimer ELISA kit |
|
E07D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Porcine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat D Dimer ELISA kit |
|
E02D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat D Dimer ELISA kit |
|
E02D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat D Dimer ELISA kit |
|
E02D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Rat D Dimer ELISA kit |
|
E02D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat D Dimer ELISA kit |
|
E02D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 Dog D Dimer ELISA kit |
|
E08D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Canine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog D Dimer ELISA kit |
|
E08D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Canine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog D Dimer ELISA kit |
|
E08D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Canine D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Goat D Dimer ELISA kit |
|
E01A47775 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Goat D Dimer ELISA kit |
|
E06D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Goat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat D Dimer ELISA kit |
|
E06D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Goat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat D Dimer ELISA kit |
|
E06D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Goat D Dimer ELISA kit |
|
E06D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Goat D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat D Dimer ELISA kit |
|
E06D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 Mouse D Dimer ELISA kit |
|
E01A21606 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Sheep D Dimer ELISA kit |
|
E01A100068 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Human D Dimer ELISA kit |
|
E01A4102 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Mouse D Dimer ELISA kit |
|
E03D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse D Dimer ELISA kit |
|
E03D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse D Dimer ELISA kit |
|
E03D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Mouse D Dimer ELISA kit |
|
E03D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse D Dimer ELISA kit |
|
E03D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Human D Dimer ELISA kit |
|
E01D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Human D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human D Dimer ELISA kit |
|
E01D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Human D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human D Dimer ELISA kit |
|
E01D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Human D Dimer ELISA kit |
|
E01D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Human D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human D Dimer ELISA kit |
|
E01D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Sheep D Dimer ELISA kit |
|
E14D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Sheep D Dimer ELISA kit |
|
E14D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 Human D Dimer ELISA Kit |
|
MBS723523-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Human D Dimer ELISA Kit |
|
MBS723523-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Human D Dimer ELISA Kit |
|
MBS723523-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Human D Dimer ELISA Kit |
|
MBS723523-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 Monkey D Dimer ELISA kit |
|
E01A73921 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Canine D Dimer ELISA kit |
|
E01A65207 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Rabbit D Dimer ELISA kit |
|
E01A30343 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Bovine D Dimer ELISA kit |
|
E01A82640 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Rabbit D Dimer ELISA kit |
|
E04D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rabbit D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit D Dimer ELISA kit |
|
E04D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rabbit D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit D Dimer ELISA kit |
|
E04D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Rabbit D Dimer ELISA kit |
|
E04D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rabbit D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit D Dimer ELISA kit |
|
E04D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Canine D Dimer ELISA kit |
|
E08D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Canine D Dimer ELISA kit |
|
E08D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Monkey D Dimer ELISA kit |
|
E09D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey D Dimer ELISA kit |
|
E09D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey D Dimer ELISA kit |
|
E09D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey D Dimer ELISA kit |
|
E09D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey D Dimer ELISA kit |
|
E09D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Bovine D Dimer ELISA kit |
|
E11D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Bovine D Dimer ELISA kit |
|
E11D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 Porcine D Dimer ELISA kit |
|
E01A56492 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Hamster D Dimer ELISA kit |
|
E01A104918 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Porcine D Dimer ELISA kit |
|
E07D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Porcine D Dimer ELISA kit |
|
E07D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 Chicken D Dimer ELISA kit |
|
E01A91362 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Chicken D Dimer ELISA kit |
|
E12D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Chicken D Dimer ELISA kit |
|
E12D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Hamster D Dimer ELISA kit |
|
E18D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Hamster D Dimer ELISA kit |
|
E18D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 Hamster D Dimer ELISA Kit |
|
MBS7275543-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Hamster D Dimer ELISA Kit |
|
MBS7275543-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Hamster D Dimer ELISA Kit |
|
MBS7275543-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Hamster D Dimer ELISA Kit |
|
MBS7275543-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 Positive Control for Anti-Rat MEH Antibody |
|
MEHCON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Rat CYP2C Antibody |
|
P2CCON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Rat CYP2D Antibody |
|
P2DCON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Rat CYP3A2 Antibody |
|
P3A2PTCON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Rat CYP2B1 Antibody |
|
P2B1PTCON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Human CYP3A Antibody |
|
P3ACON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Human CYP1B1 Antibody |
|
PH1B1CON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Human CYP2E1 Antibody |
|
P2E1PTCON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Human CYP1A2 Antibody |
|
P1A2CON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Rat CHP2B1/2 Antibody |
|
P2B12PTCON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Rat CYP1A1/1A2 Antibody |
|
P1ACON |
Detroit R&D |
100 uL |
EUR 98 |
 Positive Control for Anti-Human Cytochrome b5 Antibody |
|
Cb5CON |
Detroit R&D |
100 uL |
EUR 98 |
 Guinea Pig D Dimer ELISA kit |
|
E01A39057 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Guinea pig D Dimer ELISA kit |
|
E05D0224-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Guinea pig D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig D Dimer ELISA kit |
|
E05D0224-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Guinea pig D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea Pig D Dimer ELISA kit |
|
E05D0224-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Guinea pig D Dimer ELISA kit |
|
E05D0224-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Guinea pig D Dimer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea Pig D Dimer ELISA kit |
|
E05D0224-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 BG dimer |
|
HY-139673 |
MedChemExpress |
Get quote |
Ask for price |
|
Description: BG dimer is a molecular dimer organic luminogen with aggregation-induced emission. |
 Efficiency Box--HRP conjugated secondary antibodies |
|
EB-1 |
Detroit R&D |
81 vials |
EUR 193.2 |
 SLURP1 Dimer |
|
pro-2295 |
ProSpec Tany |
2µg |
EUR 60 |
|
Description: Recombinant Human Secreted LY6PLAUR Domain Containing 1 Dimer |
 PBD dimer-2 |
|
HY-148424 |
MedChemExpress |
10 mg |
EUR 3787.94 |
|
Description: PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer[1][2]. |
 Ibrutinib dimer |
|
HY-136113 |
MedChemExpress |
Get quote |
Ask for price |
|
Description: Ibrutinib dimer is a Dimer of Ibrutinib. Ibrutinib dimer is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2]. |
 Quercetin dimer |
|
MBS5787601-5mg |
MyBiosource |
5(mg |
EUR 570 |
Quercetin dimer |
|
MBS5787601-5x5mg |
MyBiosource |
5x5(mg |
EUR 2410 |
Quercetin dimer |
|
TN5488-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
|
|
|
Description: Quercetin dimer |
Quercetin dimer |
|
TN5488-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
|
|
|
Description: Quercetin dimer |
Ibrutinib dimer |
|
T11602-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
|
|
|
Description: Ibrutinib dimer |
Ibrutinib dimer |
|
T11602-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
|
|
|
Description: Ibrutinib dimer |
 Ethoxyquin dimer |
|
HY-138291 |
MedChemExpress |
1 mg |
EUR 324.68 |
|
Description: Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10?mg/kg shows hepatotoxicity in mice[1]. |
 Ethoxyquin Dimer |
|
MBS5796941-1mg |
MyBiosource |
1(mg |
EUR 220 |
Ethoxyquin Dimer |
|
MBS5796941-5mg |
MyBiosource |
5(mg |
EUR 705 |
Ethoxyquin Dimer |
|
MBS5796941-5x5mg |
MyBiosource |
5x5(mg |
EUR 3025 |
Ethoxyquin Dimer |
|
MBS6024191-1mg |
MyBiosource |
1(mg |
EUR 490 |
Ethoxyquin Dimer |
|
MBS6024191-25mg |
MyBiosource |
2.5mg |
EUR 710 |
Ethoxyquin Dimer |
|
MBS6024191-5x25mg |
MyBiosource |
5x2.5mg |
EUR 3040 |
Ethoxyquin Dimer |
|
T35620-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
|
|
|
Description: Ethoxyquin Dimer |
Ethoxyquin Dimer |
|
T35620-1mg |
TargetMol Chemicals |
1mg |
Ask for price |
|
|
|
Description: Ethoxyquin Dimer |
Ethoxyquin Dimer |
|
T35620-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
|
|
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Description: Ethoxyquin Dimer |
Ethoxyquin Dimer |
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T35620-5mg |
TargetMol Chemicals |
5mg |
Ask for price |
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Description: Ethoxyquin Dimer |
 Oxytocin antiparallel dimer |
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MBS5799907-5mg |
MyBiosource |
5(mg |
EUR 915 |
This exhibits the potential of canine in sustaining and spreading the an infection in Malaysia. As a result of occupational threat on account of frequent contact with canine and publicity to contaminated environments, canine handlers needs to be made conscious of the presence of this zoonotic illness.
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