Recombinant L-HN Fusion Antigen Derived from the L and HN Domains of Botulinum Neurotoxin B Stimulates a Protective Antibody Response Against Active Neurotoxin

Botulinum neurotoxin (BoNT) is a neurotoxin produced by Clostridium botulinum in an anaerobic setting. BoNT is probably the most poisonous protein amongst micro organism, animals, crops, and chemical substances reported thus far. BoNTs are 150 kDa proteins composed of three main useful domains: catalytic (L area, 50 kDa), translocation (HN area, 50 kDa), and receptor-binding

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